Beilstein J. Org. Chem.2021,17, 630–670, doi:10.3762/bjoc.17.55
compounds. The main cyclopropanating agents for the synthesis of monosubstituted methanofullerenes, the optimal conditions and the mechanism of the [2 + 1] cycloaddition, as well as the practical application of the target products are analyzed.
Keywords: [2 + 1]-cycloadditionprocesses; analogues of [60
derivatives with specific useful properties, creation of fundamentally new reagents for cycloaddition, and detailed studies on the multiaddition processes and the characteristics of polycyclic adducts.
The majority of researchers developing methods for C60 functionalization prefer [2 + 1] cycloaddition
processes, among which reactions leading to methanofullerenes are widely used. Two main synthetic methods for the production of methanofullerenes can be distinguished (Scheme 1): nucleophilic cyclopropanation with stabilized carbanions that occurs by the addition–cleavage mechanism – the Bingel reaction (I